Aktivace polyolové metabolické dráhy
...neboli sorbitolové cesty.
Při diabetické hyperglykemii vstupuje Glc do buněk inzulin-non-dependentních (pericyty kapilár a neurony). Aldosareduktasa katalyzuje dehydrogenaci Glc a tvoří se D-glucitol.Reakce spotřebovává NADPH, který je potřebný pro udržování hladiny nitrobuněčného glutathionu,důležitého antioxidantu. Stav zvýšeného poměru NADP+/NADPH se také nazývá diabetická pseudohypoxie.
Působením polyoldehydrogenasy (iditoldehydrogenasy) dochází k přeměně D-glucitolu na fruktozu.Polyoldehydrogenasa vykazuje vysokou aktivitu v hepatocytech, spermiích (Fru je hlavním zdrojem energie) a ovariálních buňkách.Naopak malá je její aktivita v retině, lens crystallina, ledvinných tubulech a periferních nervech, tj.tkáních, které jsou na inzulin necitlivé.
Glucitol nedifunduje snadno buněčnými membránami, a proto se hromadí a vyvolává zvýšení osmotického tlaku a tím ICT, čímž dochází k destrukci buněčných struktur.Krystaliny v takto vysoce osmotickém prostředí denaturují a vytvářejí ložiska silně rozptylující světlo.Tak vzniká diabetická katarakta, retinopatie a neuropatie.
Komentáře
Přehled komentářů
Wonderful article! We are linking to this particularly great article on our site. Keep up the good writing. loqua.munhea.se/map6.php ombre kort hГҐr
karta Г¶ver ingarГ¶ aperca.se
(aperca.se, 29. 10. 2020 13:18)
I savour, lead to I found exactly what I was looking for. You have ended my 4 day long hunt! God Bless you man. Have a great day. Bye tege.aperca.se/map2.php karta Г¶ver ingarГ¶
svart aronia bär munhea.se
(munhea.se, 28. 10. 2020 13:49)
Its like you read my mind! You seem to understand so much approximately this, like you wrote the ebook in it or something. I think that you simply could do with some p.c. to drive the message house a bit, but other than that, that is excellent blog. An excellent read. I'll certainly be back. cella.munhea.se/map1.php svart aronia bär
telenor obegränsad surf munhea.se
(munhea.se, 27. 10. 2020 2:05)
Hello, i think that i saw you visited my website so i came to “return the favor”.I am trying to find things to enhance my site!I suppose its ok to use some of your ideas!! cator.munhea.se/map7.php telenor obegrГ¤nsad surf
fГ¶r mycket kaffe munhea.se
(munhea.se, 26. 10. 2020 2:53)
Hi there, after reading this remarkable article i am also delighted to share my know-how here with friends. skywe.munhea.se/map2.php fГ¶r mycket kaffe
panilul.se
(panilul.se, 25. 10. 2020 15:23)
It's not my first time to go to see this website, i am browsing this web page dailly and get pleasant data from here all the time. panilul.se/map19.php bjГ¶rn borg sandaler herr
mГҐltid 200 kcal aperca.se
(aperca.se, 25. 10. 2020 13:04)
I will right away grab your rss feed as I can't in finding your e-mail subscription hyperlink or newsletter service. Do you've any? Kindly permit me realize in order that I may just subscribe. Thanks. fiagh.aperca.se/map10.php mГҐltid 200 kcal
sasilu.se
(sasilu.se, 24. 10. 2020 22:24)
Wow, this article is fastidious, my younger sister is analyzing these things, therefore I am going to convey her. sasilu.se/map1.php fodrade vattentäta skor
enkel kycklingfile i ugn munhea.se
(munhea.se, 24. 10. 2020 7:26)
Wow! After all I got a weblog from where I be capable of genuinely take valuable information concerning my study and knowledge. tiodo.munhea.se/map9.php enkel kycklingfile i ugn
gratis bilvärdering kvarndammen aperca.se
(aperca.se, 22. 10. 2020 4:42)
excellent submit, very informative. I wonder why the other experts of this sector do not notice this. You must proceed your writing. I am confident, you have a huge readers' base already! puzzc.aperca.se/map6.php gratis bilvärdering kvarndammen
dehllap.se
(dehllap.se, 22. 10. 2020 4:20)
naturally like your website but you need to check the spelling on several of your posts. A number of them are rife with spelling issues and I find it very bothersome to inform the reality nevertheless I will definitely come again again. dehllap.se/map1.php gula rosor stГҐr fГ¶r
baka med bovete munhea.se
(munhea.se, 21. 10. 2020 12:35)
Unquestionably believe that which you said. Your favorite justification seemed to be on the web the easiest thing to be aware of. I say to you, I definitely get irked while people think about worries that they just do not know about. You managed to hit the nail upon the top as well as defined out the whole thing without having side effect , people could take a signal. Will likely be back to get more. Thanks unex.munhea.se/map1.php baka med bovete
benmmdi.se
(benmmdi.se, 21. 10. 2020 8:43)
When some one searches for his required thing, thus he/she wishes to be available that in detail, therefore that thing is maintained over here. benmmdi.se/map13.php styr bГҐt korsord
soppa med pasta aperca.se
(aperca.se, 20. 10. 2020 5:02)
If some one desires to be updated with latest technologies then he must be go to see this website and be up to date daily. suspi.aperca.se/map5.php soppa med pasta
otertbe.se
(otertbe.se, 20. 10. 2020 3:24)
For most up-to-date news you have to go to see web and on web I found this web page as a most excellent web site for newest updates. otertbe.se/map29.php aspartic acid svenska
tumphati.se
(tumphati.se, 18. 10. 2020 21:40)
Thanks for sharing your thoughts. I really appreciate your efforts and I will be waiting for your further post thank you once again. tumphati.se/map13.php matleverans samma dag
kylskГҐpet i husvagnen blir inte kallt aperca.se
(aperca.se, 18. 10. 2020 11:29)
I delight in, lead to I discovered exactly what I used to be looking for. You've ended my four day long hunt! God Bless you man. Have a nice day. Bye spare.aperca.se/map8.php kylskГҐpet i husvagnen blir inte kallt
aliment interdit femme enceinte 1er trimestre munhea.se
(munhea.se, 18. 10. 2020 3:26)
For most up-to-date information you have to pay a visit web and on internet I found this site as a most excellent web site for most recent updates. mahi.munhea.se/map7.php aliment interdit femme enceinte 1er trimestre
persdap.se
(persdap.se, 17. 10. 2020 4:40)
I am sure this paragraph has touched all the internet viewers, its really really pleasant piece of writing on building up new website. persdap.se/map33.php kanelfyllning till kanelbullar
sälja tavlor på nätet aperca.se
(aperca.se, 16. 10. 2020 16:54)
wonderful issues altogether, you just gained a brand new reader. What could you recommend about your put up that you made some days ago? Any positive? breed.aperca.se/map3.php sälja tavlor på nätet
1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 | 31 | 32 | 33 | 34 | 35 | 36 | 37 | 38 | 39 | 40 | 41 | 42 | 43 | 44 | 45 | 46 | 47 | 48 | 49 | 50 | 51 | 52 | 53 | 54 | 55 | 56 | 57 | 58 | 59 | 60 | 61 | 62 | 63 | 64 | 65 | 66 | 67 | 68 | 69 | 70 | 71 | 72 | 73 | 74 | 75 | 76 | 77 | 78 | 79 | 80 | 81 | 82 | 83 | 84 | 85 | 86 | 87 | 88 | 89 | 90 | 91 | 92 | 93 | 94 | 95 | 96 | 97 | 98 | 99
ombre kort hГҐr munhea.se
(munhea.se, 30. 10. 2020 2:57)