Aktivace polyolové metabolické dráhy
...neboli sorbitolové cesty.
Při diabetické hyperglykemii vstupuje Glc do buněk inzulin-non-dependentních (pericyty kapilár a neurony). Aldosareduktasa katalyzuje dehydrogenaci Glc a tvoří se D-glucitol.Reakce spotřebovává NADPH, který je potřebný pro udržování hladiny nitrobuněčného glutathionu,důležitého antioxidantu. Stav zvýšeného poměru NADP+/NADPH se také nazývá diabetická pseudohypoxie.
Působením polyoldehydrogenasy (iditoldehydrogenasy) dochází k přeměně D-glucitolu na fruktozu.Polyoldehydrogenasa vykazuje vysokou aktivitu v hepatocytech, spermiích (Fru je hlavním zdrojem energie) a ovariálních buňkách.Naopak malá je její aktivita v retině, lens crystallina, ledvinných tubulech a periferních nervech, tj.tkáních, které jsou na inzulin necitlivé.
Glucitol nedifunduje snadno buněčnými membránami, a proto se hromadí a vyvolává zvýšení osmotického tlaku a tím ICT, čímž dochází k destrukci buněčných struktur.Krystaliny v takto vysoce osmotickém prostředí denaturují a vytvářejí ložiska silně rozptylující světlo.Tak vzniká diabetická katarakta, retinopatie a neuropatie.
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(LamaZer, 8. 7. 2024 19:03)
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(LamaZer, 8. 7. 2024 6:06)
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(LamaZer, 6. 7. 2024 9:52)
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(LamaZer, 6. 7. 2024 4:25)
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(LamaZer, 5. 7. 2024 19:02)
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(LamaZer, 5. 7. 2024 13:01)
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(LamaZer, 5. 7. 2024 11:05)
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(LamaZer, 5. 7. 2024 6:43)
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(LamaZer, 5. 7. 2024 2:10)
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(LamaZer, 4. 7. 2024 10:41)
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(LamaZer, 4. 7. 2024 9:13)
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(LamaZer, 4. 7. 2024 4:32)
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(LamaZer, 4. 7. 2024 3:06)
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BTC PROFIT SEARCH AND MINING PHRASES
(LamaZer, 9. 7. 2024 20:31)