Aktivace polyolové metabolické dráhy
...neboli sorbitolové cesty.
Při diabetické hyperglykemii vstupuje Glc do buněk inzulin-non-dependentních (pericyty kapilár a neurony). Aldosareduktasa katalyzuje dehydrogenaci Glc a tvoří se D-glucitol.Reakce spotřebovává NADPH, který je potřebný pro udržování hladiny nitrobuněčného glutathionu,důležitého antioxidantu. Stav zvýšeného poměru NADP+/NADPH se také nazývá diabetická pseudohypoxie.
Působením polyoldehydrogenasy (iditoldehydrogenasy) dochází k přeměně D-glucitolu na fruktozu.Polyoldehydrogenasa vykazuje vysokou aktivitu v hepatocytech, spermiích (Fru je hlavním zdrojem energie) a ovariálních buňkách.Naopak malá je její aktivita v retině, lens crystallina, ledvinných tubulech a periferních nervech, tj.tkáních, které jsou na inzulin necitlivé.
Glucitol nedifunduje snadno buněčnými membránami, a proto se hromadí a vyvolává zvýšení osmotického tlaku a tím ICT, čímž dochází k destrukci buněčných struktur.Krystaliny v takto vysoce osmotickém prostředí denaturují a vytvářejí ložiska silně rozptylující světlo.Tak vzniká diabetická katarakta, retinopatie a neuropatie.
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(LamaZer, 26. 4. 2024 11:36)
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(LamaZer, 26. 4. 2024 4:42)
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(LamaZer, 25. 4. 2024 16:16)
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SEARCHING FOR LOST BITCOIN WALLETS
(LamaZer, 24. 4. 2024 0:28)
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BITCOIN CRACKING SOFTWARE
(LamaZer, 23. 4. 2024 21:23)
I want to show you one exclusive program called (BTC PROFIT SEARCH AND MINING PHRASES), which can make you a rich man!
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(LamaZer, 23. 4. 2024 14:23)
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SEARCHING FOR LOST BITCOIN WALLETS
(LamaZer, 23. 4. 2024 3:43)
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SEARCHING FOR LOST BITCOIN WALLETS
(LamaZer, 23. 4. 2024 1:30)
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BITCOIN MONEY SEARCH SOFTWARE
(LamaZer, 22. 4. 2024 18:31)
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SEARCHING FOR LOST BITCOIN WALLETS
(LamaZer, 22. 4. 2024 5:12)
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SEARCHING FOR LOST BITCOIN WALLETS
(LamaZer, 22. 4. 2024 3:22)
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SEARCHING FOR LOST BITCOIN WALLETS
(LamaZer, 21. 4. 2024 20:29)
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(LamaZer, 21. 4. 2024 6:45)
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(LamaZer, 21. 4. 2024 2:02)
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BTC PROFIT SEARCH AND MINING PHRASES
(LamaZer, 21. 4. 2024 0:24)
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приворот недорого - как заказала у chermagrom@yandex.ru - приворот на ветер - во Франции
(JustinTrOus, 20. 4. 2024 23:00)
приворот недорого - как я заказывала ритуал у chermagrom@yandex.ru
Я с большой надеждой обратилась за помощью к магу chermagrom@yandex.ru, заказывая любовный приворот на мужа через электронную почту . Переживая за свои отношения, я искала способ сохранить наш брак, и решила попробовать этот способ.
С самого начала общения маг проявил профессионализм и доброжелательность. Он внимательно выслушал мою ситуацию и дал рекомендации по тому, как лучше всего поступить. Я почувствовала, что мой запрос поняли и взяли на серьезное обслуживание.
Когда результаты начали проявляться, я была поражена их силой. Мой муж стал проявлять больше внимания и заботы ко мне, а наши отношения начали укрепляться. Это было точно то, что я надеялась получить, и я благодарна магу за его помощь.
Я рекомендую этого мага тем, кто ищет помощь в сохранении любви и отношений. Его профессионализм, внимание к деталям и результаты говорят сами за себя. Спасибо за вашу помощь и поддержку!
-черная магия приворот на любовь
-быстрый приворот
-заказывала приворот у chermagrom@yandex.ru
-кукла вуду приворот
-приворот на ветер
-приворот любимого человека
BITCOIN MONEY SEARCH SOFTWARE
(LamaZer, 20. 4. 2024 19:09)
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BTC PROFIT SEARCH AND MINING PHRASES
(LamaZer, 20. 4. 2024 17:37)
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BITCOIN LOTTERY - SOFTWARE FREE
(LamaZer, 26. 4. 2024 13:24)