Aktivace polyolové metabolické dráhy
...neboli sorbitolové cesty.
Při diabetické hyperglykemii vstupuje Glc do buněk inzulin-non-dependentních (pericyty kapilár a neurony). Aldosareduktasa katalyzuje dehydrogenaci Glc a tvoří se D-glucitol.Reakce spotřebovává NADPH, který je potřebný pro udržování hladiny nitrobuněčného glutathionu,důležitého antioxidantu. Stav zvýšeného poměru NADP+/NADPH se také nazývá diabetická pseudohypoxie.
Působením polyoldehydrogenasy (iditoldehydrogenasy) dochází k přeměně D-glucitolu na fruktozu.Polyoldehydrogenasa vykazuje vysokou aktivitu v hepatocytech, spermiích (Fru je hlavním zdrojem energie) a ovariálních buňkách.Naopak malá je její aktivita v retině, lens crystallina, ledvinných tubulech a periferních nervech, tj.tkáních, které jsou na inzulin necitlivé.
Glucitol nedifunduje snadno buněčnými membránami, a proto se hromadí a vyvolává zvýšení osmotického tlaku a tím ICT, čímž dochází k destrukci buněčných struktur.Krystaliny v takto vysoce osmotickém prostředí denaturují a vytvářejí ložiska silně rozptylující světlo.Tak vzniká diabetická katarakta, retinopatie a neuropatie.
Komentáře
Přehled komentářů
It is perfect time to make some plans for the future and it's time to be happy. I've read this post and if I could I wish to suggest you some interesting things or tips. Maybe you can write next articles referring to this article. I wish to read more things about it!
Test, just a test
(DavidWhaks, 25. 9. 2021 4:04)
Hello guys. And Bye.
neversurrenderboys ;)
real bodyrub massage in New Yourk
(Craigabarp, 23. 9. 2021 11:51)
https://body-rub.manhattan-massage.com/ - upscale bodyrub new york
Wish you feel memorable emotions ? Tired of work ? How about to have a rest and massage ? We invite you to visit massage salon in West Village.
Where can be ordered Thai massage in salons Midwood.
Massage periosteal performed masseurs
, their possibly meet by coming to our club . Girls are attractive slim figures and appearance . You always have the opportunity experience for yourself aesthetic satisfaction, just looking at them.
Our salon works around the clock .
Running massage Thai without intimate actions , what make it safe. Spa in Clinton Hill comply with rules hygiene , use disposable personal items .In the cabin vibration massage you acquire not so much massage but also opportunity relax to body and to soul.
Also our staff store your personal privacy: on the matter what way in particular you prefer to spend free time, not will know no person.
Massage in spa Windsor Terrace possibly attend people from 21 years. By calling to the salon by phone, you can sign up for necessary day and time . Spa Salon with great pleasure will welcome you.
XXX Porn Tube
(RobertZef, 22. 9. 2021 16:02)
XXX Home Free XXX Porn
XXX Free Porn Tube
XXX Japan Porn Free Japan Porn
XXX Japanese Porn Tube Japan Porn
XXXhome Porn Tube Video
XXXChina Porn Tube
XXX Japanese Porn Tube Japan Porn
Japan Porn Video XXX Japan Porn Tube
https://cn.xxxcomvideo.com/224
https://zh.xxxwww1.com/139
https://zh.xxxwww1.com/211
https://zh.xxxwww1.com/149
https://zh.xxxwww1.com/127
https://zh.xxxwww1.com/145
Drums
(KennethAcene, 4. 9. 2021 21:21)
Music has tied us
Keyboards & Pianos
https://fas.st/NNXXI
Drums & Percussion
https://fas.st/Vay4s
String Instruments
https://fas.st/32jbD
String Instruments
(MiltonWeile, 4. 9. 2021 2:41)
Music has tied us
Keyboards & Pianos
https://fas.st/NNXXI
Drums & Percussion
https://fas.st/Vay4s
String Instruments
https://fas.st/32jbD
Sale
(Justinzex, 28. 8. 2021 6:49)
On the site you can order women's clothing wholesale and retail from the manufacturer as cheaply as possible.
A variety of models and a wide range of sizes for the owners of any shape are our strengths that distinguish us from our competitors.
https://fas.st/qDM1g
Gay blog
(RobertTarly, 17. 8. 2021 15:56)
https://www.google.com/url?q=https://bear-magazine.com/gay-nazi/
https://images.google.be/url?q=https://bear-magazine.com/gay-dating-apps-in-ghana/
https://cse.google.mu/url?q=https://bear-magazine.com/gay-old-men/
https://www.google.com/url?q=https://bear-magazine.com/gay-dating-4you-de/
https://images.google.be/url?q=https://bear-magazine.com/gay-friends/
https://www.google.com/url?q=https://bear-magazine.com/gay-in-latex/
https://sandbox.google.com/url?q=https://bear-magazine.com/bagdad-gay/
https://images.google.be/url?q=https://bear-magazine.com/free-gay-daddy/
https://plus.google.com/url?q=https://bear-magazine.com/gay-dating-in-reutlingen/
https://maps.google.com.pr/url?q=https://bear-magazine.com/gay-love-songs/
Marketplace
(MiltonWeile, 7. 8. 2021 23:12)
This is a unique place for fashionable women's clothing and accessories.
We offer our clients women's clothing, jewelry, cosmetics and health products, shoes, bags and much more.
https://Newchic.vip/Zte4
Quality products and drugs only here https://bit.ly/3wlPWWx
(clonS, 31. 7. 2021 12:45)
Follow the link and choose the products for your health
https://bit.ly/3rLBBis
Četl jsi to? Pak XRumer a XEvil pracují!!
(MashaaTug9757, 26. 7. 2021 23:06)
Četl jsi to? Pak XRumer a XEvil pracují!!
Chcete zveřejnit svůj text na 12.000.000 (12 milióny!) webové stránky? Žádný problém-s novým softwarovým komplexem "XEvil 5.0 + XRumer 19.0.8"!
Blogy, fóra, desky, obchody, knihy návštěv, sociální sítě - všechny motory s jakýmkoli captcha!
XEvil také kompatibilní s jakýmikoli SEO / SMM programy a skripty a může přijímat captcha z jakéhokoli zdroje. Jen to zkuste! ;)
Pozdrav, MasheTug9191
P.S. Obrovské slevy jsou k dispozici (až 50%!) pro krátkou recenzi o Xevilu na jakémkoli populárním fóru nebo platformě. Stačí požádat oficiální podporu o slevu!
LarryThedy
(LarryThedy, 24. 7. 2021 12:35)
Hello my friend! I wish to say that this article is awesome, great written and come with almost all vital infos. I would like to see extra posts like this .
https://vk.com/kupludom24
(BobbyHem, 18. 7. 2021 15:21)
<a href=https://vk.com/kupludom24>Продам дом Красноярск
Frankperia
(Frankperia, 10. 7. 2021 13:02)
Helpful information. Fortunate me I discovered your web site by chance, and I am shocked why this coincidence did not took place earlier! I bookmarked it.
Quality products and drugs only here https://bit.ly/3rLBBis
(clonS, 9. 7. 2021 17:37)
Quality medical products at a low cost. Worldwide delivery
https://bit.ly/3rLBBis
Very much a prompt reply :)
(KevinMet, 8. 7. 2021 5:58)
I consider, that you are not right. I am assured. Let's discuss. Write to me in PM, we will communicate.
Bravo, your phrase simply excellent
(Scottyovata, 8. 7. 2021 5:57)
I think, that you are not right. I can prove it. Write to me in PM, we will talk.
Major
(KennethAcene, 7. 7. 2021 21:43)
This is a unique place for fashionable women's clothing and accessories.
We offer our clients women's clothing, jewelry, cosmetics and health products, shoes, bags and much more.
https://fas.st/Ujfha
I consider, that you are not right. I can prove it. Write to me in PM, we will discuss.
(Carlosnuamb, 7. 7. 2021 14:38)
In it something is. Clearly, many thanks for the information.
1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 | 31 | 32 | 33 | 34 | 35 | 36 | 37 | 38 | 39 | 40 | 41 | 42 | 43 | 44 | 45 | 46 | 47 | 48 | 49 | 50 | 51 | 52 | 53 | 54 | 55 | 56 | 57 | 58 | 59 | 60 | 61 | 62 | 63 | 64 | 65 | 66 | 67 | 68
Hi
(WilliamTesse, 21. 10. 2021 18:58)