Aktivace polyolové metabolické dráhy
...neboli sorbitolové cesty.
Při diabetické hyperglykemii vstupuje Glc do buněk inzulin-non-dependentních (pericyty kapilár a neurony). Aldosareduktasa katalyzuje dehydrogenaci Glc a tvoří se D-glucitol.Reakce spotřebovává NADPH, který je potřebný pro udržování hladiny nitrobuněčného glutathionu,důležitého antioxidantu. Stav zvýšeného poměru NADP+/NADPH se také nazývá diabetická pseudohypoxie.
Působením polyoldehydrogenasy (iditoldehydrogenasy) dochází k přeměně D-glucitolu na fruktozu.Polyoldehydrogenasa vykazuje vysokou aktivitu v hepatocytech, spermiích (Fru je hlavním zdrojem energie) a ovariálních buňkách.Naopak malá je její aktivita v retině, lens crystallina, ledvinných tubulech a periferních nervech, tj.tkáních, které jsou na inzulin necitlivé.
Glucitol nedifunduje snadno buněčnými membránami, a proto se hromadí a vyvolává zvýšení osmotického tlaku a tím ICT, čímž dochází k destrukci buněčných struktur.Krystaliny v takto vysoce osmotickém prostředí denaturují a vytvářejí ložiska silně rozptylující světlo.Tak vzniká diabetická katarakta, retinopatie a neuropatie.
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(DennyCah, 7. 3. 2024 7:02)
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BTC PROFIT SEARCH AND MINING PHRASES
(LamaZer, 7. 3. 2024 5:06)
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(EsbeHurdy, 7. 3. 2024 4:14)interesting news
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(LamaZer, 7. 3. 2024 1:24)
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SEARCHING FOR LOST BITCOIN WALLETS
(LamaZer, 7. 3. 2024 0:17)
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(DennyCah, 6. 3. 2024 22:46)
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BITCOIN MONEY SEARCH SOFTWARE
(LamaZer, 6. 3. 2024 18:52)
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Germay News Today
(Phillipzed, 6. 3. 2024 18:41)
Germay Latest Breaking News, Pictures, Videos, and Special Reports from Germay News Today. Germay Blogs, Comments and Archive News.
https://www.germaynewstoday.com/
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BTC PROFIT SEARCH AND MINING PHRASES
(LamaZer, 8. 3. 2024 1:29)