Aktivace polyolové metabolické dráhy
...neboli sorbitolové cesty.
Při diabetické hyperglykemii vstupuje Glc do buněk inzulin-non-dependentních (pericyty kapilár a neurony). Aldosareduktasa katalyzuje dehydrogenaci Glc a tvoří se D-glucitol.Reakce spotřebovává NADPH, který je potřebný pro udržování hladiny nitrobuněčného glutathionu,důležitého antioxidantu. Stav zvýšeného poměru NADP+/NADPH se také nazývá diabetická pseudohypoxie.
Působením polyoldehydrogenasy (iditoldehydrogenasy) dochází k přeměně D-glucitolu na fruktozu.Polyoldehydrogenasa vykazuje vysokou aktivitu v hepatocytech, spermiích (Fru je hlavním zdrojem energie) a ovariálních buňkách.Naopak malá je její aktivita v retině, lens crystallina, ledvinných tubulech a periferních nervech, tj.tkáních, které jsou na inzulin necitlivé.
Glucitol nedifunduje snadno buněčnými membránami, a proto se hromadí a vyvolává zvýšení osmotického tlaku a tím ICT, čímž dochází k destrukci buněčných struktur.Krystaliny v takto vysoce osmotickém prostředí denaturují a vytvářejí ložiska silně rozptylující světlo.Tak vzniká diabetická katarakta, retinopatie a neuropatie.
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Живу я в большом городе, и найти среди кучи «магов» хорошего, трудно. Намучилась я с этим очень. И как бывает, все решается на пьяную голову. Сидели с двоюродной сестрой, поведала ей свою проблему с мужем и о бесконечных поисках магов. Она очень удивилась, что я сразу не стала искать человека с Якутии или другого региона Дальнего востока – это можно сказать родина многих сильных шаманов и колдунов.
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Перед тем, как обратиться к нему, моя ситуация с мужем казалась мне безвыходной. Наш брак испытывал серьезные трудности, и наши отношения становились все более напряженными.
Мой муж, с которым мы прожили много лет, казался мне все более отстраненным и равнодушным. Он уходил в себя, избегал общения, а наши разговоры становились все реже и поверхностнее. Я испытывала огромную боль от того, что наша семья распадается, и что я теряю своего мужа. В итоге он еще и любовницу завел.
После долгих раздумий и поиска решения проблемы, я решила обратиться к магу Роману Петровичу за помощью.
Он провел для меня приворот на мужа – на все ушло 5 дней, и еще дал ряд простых рекомендаций, которым нужно было следовать до получения результата. Последовали дни ожидания
На 5 день после проведения приворота я почувствовала изменения в поведении мужа. Он стал проявлять больше внимания и заботы, мы снова начали общаться и находить общие интересы. Стали возвращаться чувства и заинтересованность мной как женщиной. Все быстро нормлизовалось в наших отношениях, с любовницей он порвал все контакты.
Сейчас, спустя несколько месяцев после проведения приворота, я вижу, что наш брак стал крепким, стабильным и счастливым, как и раньше! Мы с мужем снова чувствуем себя близкими и любящими людьми.
Я благодарна магу Роману Петровичу за его помощь и поддержку в трудный момент!
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Ну что, зажжем сегодня?
(Larrynug, 1. 3. 2024 13:13)