Aktivace polyolové metabolické dráhy
...neboli sorbitolové cesty.
Při diabetické hyperglykemii vstupuje Glc do buněk inzulin-non-dependentních (pericyty kapilár a neurony). Aldosareduktasa katalyzuje dehydrogenaci Glc a tvoří se D-glucitol.Reakce spotřebovává NADPH, který je potřebný pro udržování hladiny nitrobuněčného glutathionu,důležitého antioxidantu. Stav zvýšeného poměru NADP+/NADPH se také nazývá diabetická pseudohypoxie.
Působením polyoldehydrogenasy (iditoldehydrogenasy) dochází k přeměně D-glucitolu na fruktozu.Polyoldehydrogenasa vykazuje vysokou aktivitu v hepatocytech, spermiích (Fru je hlavním zdrojem energie) a ovariálních buňkách.Naopak malá je její aktivita v retině, lens crystallina, ledvinných tubulech a periferních nervech, tj.tkáních, které jsou na inzulin necitlivé.
Glucitol nedifunduje snadno buněčnými membránami, a proto se hromadí a vyvolává zvýšení osmotického tlaku a tím ICT, čímž dochází k destrukci buněčných struktur.Krystaliny v takto vysoce osmotickém prostředí denaturují a vytvářejí ložiska silně rozptylující světlo.Tak vzniká diabetická katarakta, retinopatie a neuropatie.
Komentáře
Přehled komentářů
https://strana-rf.ru/2022/04/25/biorazlagaemye-pakety-dlya-musora-poleznye-svojstva/
Modern economic problems
(Brianlit, 25. 5. 2023 10:32)
https://strana-rf.ru/2022/04/25/biorazlagaemye-pakety-dlya-musora-poleznye-svojstva/
Modern economic problems
(Brianlit, 25. 5. 2023 10:31)
https://strana-rf.ru/2022/04/25/biorazlagaemye-pakety-dlya-musora-poleznye-svojstva/
Modern economic problems
(Brianlit, 25. 5. 2023 10:30)
https://strana-rf.ru/2022/04/25/biorazlagaemye-pakety-dlya-musora-poleznye-svojstva/
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Modern economic problems
(Matthewscoth, 22. 5. 2023 3:16)
https://twitter.com/mauerburo59/status/594481257733607424
Modern economic problems
(Matthewscoth, 22. 5. 2023 3:14)
https://twitter.com/mauerburo59/status/594481257733607424
Modern economic problems
(Matthewscoth, 22. 5. 2023 3:12)
https://twitter.com/mauerburo59/status/594481257733607424
Modern economic problems
(Matthewscoth, 22. 5. 2023 3:11)
https://twitter.com/mauerburo59/status/594481257733607424
Modern economic problems
(Matthewscoth, 22. 5. 2023 3:10)
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(Williambeddy, 21. 5. 2023 22:54)
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Thank
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Modern economic problems
(Brianlit, 25. 5. 2023 10:33)